Tshz3^tm2.1Lafa
Targeted Allele Detail

Summary

• Symbol: Tshz3^tm2.1Lafa
• Name: teashirt zinc finger family member 3; targeted mutation 2.1, Laurent Fasano
• MGI ID: MGI:7261361
• Synonyms: Tshz3^flox
• Gene: Tshz3 Location: Chr7:36397543-36472978 bp, + strand Genetic Position: Chr7, 22.79 cM
• Alliance: Tshz3^tm2.1Lafa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:294534
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and FRt-flanked neomycin selection cassette were inserted upstream of exon 2 and a a second loxP site was inserted downstream of the 3' UTR. The neomycin cassette was removed via flp-mediated recombination. (J:294534)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tshz3 Mutation: 39 strains or lines available

References

• Original: J:294534 Chabbert D, et al., Postnatal Tshz3 Deletion Drives Altered Corticostriatal Function and Autism Spectrum Disorder-like Behavior. Biol Psychiatry. 2019 Aug 15;86(4):274-285
• All: 2 reference(s)