Tg(KRT18*R89C)50Rgo
Transgene Detail

Summary

• Symbol: Tg(KRT18*R89C)50Rgo
• Name: transgene insertion 50, Robert G Oshima
• MGI ID: MGI:7262691
• Transgene: Tg(KRT18*R89C)50Rgo Location: unknown
• Alliance: Tg(KRT18*R89C)50Rgo page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Dominant negative, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT18*R89C)50Rgo expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  KRT18 (3875)

  Krt18

  (MGI:96692)

• Mutation details: This transgene consists of the human keratin 18 cDNA containing an arginine to cysteine substitution at amino acid 89 in exon 1. Three lines were generated; F22, F30, and F50. The transgene copy number for line F50 is 18. The relative protein ratio of endogenous mouse Krt18 to over-expressed human KRT18 is 1:1. (J:241700)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:241700 Ku NO, et al., Chronic hepatitis, hepatocyte fragility, and increased soluble phosphoglycokeratins in transgenic mice expressing a keratin 18 conserved arginine mutant. J Cell Biol. 1995 Dec;131(5):1303-14
• All: 2 reference(s)