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Clec2htm1.1Apma
Targeted Allele Detail
Summary
Symbol: Clec2htm1.1Apma
Name: C-type lectin domain family 2, member h; targeted mutation 1.1, Andrew P Makrigiannis
MGI ID: MGI:7262867
Synonyms: Clr-f-
Gene: Clec2h  Location: Chr6:128639348-128654337 bp, + strand  Genetic Position: Chr6, 63.07 cM, cytoband F3
Alliance: Clec2htm1.1Apma page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:322835
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neomycin selection cassette flanked by loxP sites replaced exons 3 and 4 and part of exon 5. The neomycin cassette was removed via flp-mediated recombination. RT-PCR conformed the complete loss of transcript and immunofluorescent labeling of the kidney and small intestine confirmed the absence of protein. In addition, protein expression of NKRP1G, which lies in apposition to this gene, is not affected. (J:322835)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Clec2h Mutation:  15 strains or lines available
References
Original:  J:322835 Zein HS, et al., Clr-f expression regulates kidney immune and metabolic homeostasis. Sci Rep. 2022 Mar 22;12(1):4834
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory