Cftr^tm1.1Sdw
Targeted Allele Detail

Summary

• Symbol: Cftr^tm1.1Sdw
• Name: cystic fibrosis transmembrane conductance regulator; targeted mutation 1.1, Steve D Wilton
• MGI ID: MGI:7263374
• Synonyms: Cftr^delta9
• Gene: Cftr Location: Chr6:18170686-18322767 bp, + strand Genetic Position: Chr6, 8.1 cM, cytoband A3
• Alliance: Cftr^tm1.1Sdw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:323560
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Intragenic deletion
• Exon 9 was flanked with loxP sites. Cre-mediated recombination deleted exon 9 in the germline. (J:323560)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cftr Mutation: 98 strains or lines available

References

• Original: J:323560 Martinovich KM, et al., Investigating the Implications of CFTR Exon Skipping Using a Cftr Exon 9 Deleted Mouse Model. Front Pharmacol. 2022;13:868863
• All: 1 reference(s)