Foxn1^{em1(icre)Smoc}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Foxn1^{em1(icre)Smoc}
• Name: forkhead box N1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:7263400
• Gene: Foxn1 Location: Chr11:78248403-78277384 bp, - strand Genetic Position: Chr11, 46.74 cM
• Alliance: Foxn1^{em1(icre)Smoc} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Foxn1^{em1(icre)Smoc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Foxn1 (MGI:102949)

• Mutation details: A IRES-iCre expression cassette was knocked into the Foxn1 gene stop codon site. The protein encoded by Foxn1 (forkhead box N1) gene is part of the forkhead family or "winged-helix" transcription factors that are important in developmental processes, immune system regulation, metabolism, cancer and aging. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in thymic epithelial cell and keratinocytes (J:238766)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Foxn1 (mouse) Summary of all recombinase alleles driven by Foxn1. Alliance mouse Foxn1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxn1 Mutation: 106 strains or lines available

References

• Original: J:238766 Shanghai Model Organisms Center, Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China. MGI Direct Data Submission. 2017
• All: 1 reference(s)