Mirc33^em1Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mirc33^em1Smoc
• Name: microRNA cluster 33, including Mir29a through Mir29b-1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:7264934
• Synonyms: Mir29a^em1 Mir29b-1^em1Smoc
• Gene: Mirc33 Location: Chr6:31039595-31040028 bp Genetic Position: Chr6, Syntenic

Mutation origin

• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A 0.6kb region in length including Mir29a and Mir29b-1 pre-microRNAs was removed in this strain. Real-time PCR analysis demonstrated absence of mature Mir29a RNA in various tissues of homozygous mutant mice. Precursor RNA levels of pre-Mir29a or pre-Mir29a were reduced in heterozygous mice and nearly undetectable in homozygous mutant mice. (J:238766, J:324059)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc33 Mutation: 0 strains or lines available

References

• Original: J:238766 Shanghai Model Organisms Center, Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China. MGI Direct Data Submission. 2017
• All: 3 reference(s)