Tnfaip3^m1Apb
Chemically induced Allele Detail

Summary

• Symbol: Tnfaip3^m1Apb
• Name: tumor necrosis factor, alpha-induced protein 3; mutation 1, Australian Phenomics Facility
• MGI ID: MGI:7266848
• Synonyms: Tnfaip3^I325N, Tnfaip3^lasvegas
• Gene: Tnfaip3 Location: Chr10:18876658-18891158 bp, - strand Genetic Position: Chr10, 8.08 cM
• Alliance: Tnfaip3^m1Apb page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis created a mutation changing isoleucine codon 325 (ATC) to asparagine (AAC) (c.974T>A, p.I325N). (J:283545)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnfaip3 Mutation: 45 strains or lines available

References

• Original: J:283545 Zammit NW, et al., Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity. Nat Immunol. 2019 Oct;20(10):1299-1310
• All: 2 reference(s)