Kdm2b^tm1.1Hko
Targeted Allele Detail

Summary

• Symbol: Kdm2b^tm1.1Hko
• Name: lysine (K)-specific demethylase 2B; targeted mutation 1.1, Haruhiko Koseki
• MGI ID: MGI:7278775
• Synonyms: Kdm2b^fl
• Gene: Kdm2b Location: Chr5:123008727-123127333 bp, - strand Genetic Position: Chr5, 62.63 cM, cytoband F
• Alliance: Kdm2b^tm1.1Hko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:296282
• Parent Cell Line: MS12 (ES Cell)
• Strain of Origin: C57BL/6NSlc

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exon 13, which encodes most of the KDM2B ZF-CxxC domain and is shared by both the long and short form of the protein, was flanked by loxP sites. A neomycin resistant gene cassette flanked with FRT sites was removed in ES cells prior to the generation of mutant mice. (J:296282)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kdm2b Mutation: 219 strains or lines available

References

• Original: J:296282 Blackledge NP, et al., Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation. Cell. 2014 Jun 5;157(6):1445-59
• All: 3 reference(s)