Rnaseh2b^em1Anu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rnaseh2b^em1Anu
• Name: ribonuclease H2, subunit B; endonuclease-mediated mutation 1, Australian National University
• MGI ID: MGI:7279261
• Gene: Rnaseh2b Location: Chr14:62569517-62610445 bp, + strand Genetic Position: Chr14, 33.19 cM, cytoband C3
• Alliance: Rnaseh2b^em1Anu page

Mutation origin

• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISRP-targeting deleted 1 bp , leading to a premature stop codon at amino acid 175. (J:324448)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnaseh2b Mutation: 43 strains or lines available

References

• Original: J:324448 Brown GJ, et al., TLR7 gain-of-function genetic variation causes human lupus. Nature. 2022;605(7909):349-356
• All: 1 reference(s)