Hnmttm1c(KOMP)Wtsi
Targeted Allele Detail
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Symbol: |
Hnmttm1c(KOMP)Wtsi |
Name: |
histamine N-methyltransferase; targeted mutation 1c, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:7279265 |
Synonyms: |
HNMTf |
Gene: |
Hnmt Location: Chr2:23892922-23939406 bp, - strand Genetic Position: Chr2, 16.06 cM
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Alliance: |
Hnmttm1c(KOMP)Wtsi page
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Mutant Cell Line: |
EPD0109_4_D09 |
Germline Transmission: |
Earliest citation of germline transmission:
J:324455
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Parent Cell Line: |
JM8.F6 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
Vector: L1L2_Bact_P
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Mutation details: The L1L2_Bact_P cassette was inserted at position 23935417 of Chromosome 2 upstream of the critical exon 3 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 3 at position 23936162. The critical exon 3 is thus flanked by loxP sites. Flp-mediated recombination removed the lacZ and neomycin resistance gene and generated a "conditional read" allele with exon 3 floxed.
(J:324455)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Hnmt Mutation: |
19 strains or lines available
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Original: |
J:324455 Otsuka R, et al., Contribution of astrocytic histamine N-methyltransferase to histamine clearance and brain function in mice. Neuropharmacology. 2022 Jul 1;212:109065 |
All: |
1 reference(s) |
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