Septin12^em1Lych
Endonuclease-mediated Allele Detail

Summary

• Symbol: Septin12^em1Lych
• Name: septin 12; endonuclease-mediated mutation 1, Lingyi Chen
• MGI ID: MGI:7280674
• Synonyms: Septin12^-
• Gene: Septin12 Location: Chr16:4804722-4815716 bp, - strand Genetic Position: Chr16, 2.49 cM, cytoband A1
• Alliance: Septin12^em1Lych page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology deleted nearly the whole open reading frame. (J:324492)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Septin12 Mutation: 25 strains or lines available

References

• Original: J:324492 Chen H, et al., Homozygous Loss of Septin12, but not its Haploinsufficiency, Leads to Male Infertility and Fertilization Failure. Front Cell Dev Biol. 2022;10:850052
• All: 1 reference(s)