Phf6^em1Wencc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Phf6^em1Wencc
• Name: PHD finger protein 6; endonuclease-mediated mutation 1, Wen-Chien Chou
• MGI ID: MGI:7280677
• Synonyms: Phf6^F
• Gene: Phf6 Location: ChrX:52001143-52045820 bp, + strand Genetic Position: ChrX, 29.28 cM, cytoband A4
• Alliance: Phf6^em1Wencc page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• LoxP sites were inserted into intron 1 and downstream of exon 11 using CRISPR/Cas9 technology. (J:278804)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Phf6 Mutation: 12 strains or lines available

References

• Original: J:278804 Hsu YC, et al., Phf6-null hematopoietic stem cells have enhanced self-renewal capacity and oncogenic potentials. Blood Adv. 2019 Aug 13;3(15):2355-2367
• All: 2 reference(s)