Pdyn^tm1.1Jdin
Targeted Allele Detail

Summary

• Symbol: Pdyn^tm1.1Jdin
• Name: prodynorphin; targeted mutation 1.1, Jun Ding
• MGI ID: MGI:7281313
• Synonyms: pDyn^fl
• Gene: Pdyn Location: Chr2:129528485-129541764 bp, - strand Genetic Position: Chr2, 63.19 cM
• Alliance: Pdyn^tm1.1Jdin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:350550
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The allele is created using a BAC clone containing exon 4 genomic sequence of the gene. The targeting construct was inserted into intron 3 and includes a loxP site followed by an FRT-flanked neomycin/kanamycin selection cassette and a second loxP site located downstream of exon 4. FLP-mediated recombination removed the neo/kan cassette. (J:350550)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pdyn Mutation: 20 strains or lines available

References

• Original: J:350550 Yang R, et al., Dichotomous regulation of striatal plasticity by dynorphin. Mol Psychiatry. 2023 Jan;28(1):434-447
• All: 1 reference(s)