Tg(Postn-icre/ERT2)#Wet
Transgene Detail

Summary

• Symbol: Tg(Postn-icre/ERT2)#Wet
• Name: transgene insertion, Nina Wettschureck
• MGI ID: MGI:7281316
• Synonyms: PnCreERT2, Postn-iCre
• Transgene: Tg(Postn-icre/ERT2)#Wet Location: unknown
• Alliance: Tg(Postn-icre/ERT2)#Wet page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Postn-icre/ERT2)#Wet expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Postn (MGI:1926321)

• Mutation details: A cassette consisting of the CreERT2 cDNA followed by a polyadenylation signal from bovine growth hormone was introduced after the start codon of the mouse Postn gene carried by BAC RP23-480C1 using Red E/T-mediated recombination. After homologous recombination and Flp-mediated excision of the ampicillin cassette, the construct was injected into oocytes of C57/BL6 mice. Five founder lines were generated and characterized. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:254071)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Postn (mouse) Summary of all recombinase alleles driven by Postn. Comparative matrix view of recombinase activities Alliance mouse Postn gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:254071 Kaur H, et al., Targeted Ablation of Periostin-Expressing Activated Fibroblasts Prevents Adverse Cardiac Remodeling in Mice. Circ Res. 2016 Jun 10;118(12):1906-17
• All: 2 reference(s)