Oxtr^{em2(icre)Yinn}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Oxtr^{em2(icre)Yinn}
• Name: oxytocin receptor; endonuclease-mediated mutation 2, Yukiko U Inoue
• MGI ID: MGI:7282234
• Synonyms: Oxtr^1xPA-iCre, Oxtr^{em1(icre)Inot}, Oxtr-T2A-iCre
• Gene: Oxtr Location: Chr6:112450644-112466904 bp, - strand Genetic Position: Chr6, 52.27 cM, cytoband E3
• Alliance: Oxtr^{em2(icre)Yinn} page

Mutation origin

• Strain of Origin: (C57BL/6 x C3H)F1

Mutation description

• Allele Type: Endonuclease-mediated (Epitope tag, Recombinase)
• Mutation: Insertion
• Oxtr^{em2(icre)Yinn} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Oxtr (MGI:109147)

• Mutation details: Using CRISPR/cas9 technology, a 1xPA-tag and a T2A-iCre expression cassette were inserted into the Oxtr gene just upstream of the stop codon. (J:314171)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Oxtr (mouse) Summary of all recombinase alleles driven by Oxtr. Comparative matrix view of recombinase activities Alliance mouse Oxtr gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Oxtr Mutation: 41 strains or lines available

References

• Original: J:314171 Inoue YU, et al., An Optimized Preparation Method for Long ssDNA Donors to Facilitate Quick Knock-In Mouse Generation. 7 new recombinases (including the one already entered), and 5 different reporter alleles. Cells. 2021 Apr 30;10(5)
• All: 2 reference(s)