Avpr2^tm2.1Jwe
Targeted Allele Detail

Summary

• Symbol: Avpr2^tm2.1Jwe
• Name: arginine vasopressin receptor 2; targeted mutation 2.1, Jurgen Wess
• MGI ID: MGI:7282271
• Synonyms: V2R^fl
• Gene: Avpr2 Location: ChrX:72935371-72938034 bp, + strand Genetic Position: ChrX, 37.46 cM
• Alliance: Avpr2^tm2.1Jwe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:324922
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1 (185 bp downstream of the ATG start codon) and a loxP-flanked neomycin cassette was inserted into intron 2. Cre-mediated recombination removed the neomycin cassette generating a conditional allele. The coding sequence is disrupted by two short introns (1 and 2) and it is this middle intron that is floxed. (J:324922)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Avpr2 Mutation: 1 strain or line available

References

• Original: J:324922 Li JH, et al., A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus. J Clin Invest. 2009 Oct;119(10):3115-26
• All: 2 reference(s)