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Pak1em2Yuwa
Endonuclease-mediated Allele Detail
Summary
Symbol: Pak1em2Yuwa
Name: p21 (RAC1) activated kinase 1; endonuclease-mediated mutation 2, Yuichi Wakabayashi
MGI ID: MGI:7284812
Synonyms: Pak1-3''UTR-171A
Gene: Pak1  Location: Chr7:97437748-97561588 bp, + strand  Genetic Position: Chr7, 53.57 cM
Alliance: Pak1em2Yuwa page
Mutation
origin
Strain of Origin:  FVB/N
Mutation
description
Allele Type:    Endonuclease-mediated (No functional change)
Mutation:    Single point mutation
 
Mutation detailsUsing an sgRNA (targeting GCACTGAAGAGAATTGCATCTGG) and an ssODN templates (CTGCTGGATTACTCGTCCAGATGCAATTCTCTTCAGTGCTAGACAGTTTC) with CRISPR technology, 3' UTR mutation c.*171T>A (minor allele of SNP rs3654376) was introduced to make the 3' UTR in this FVB/N strain similar to that in the MSM/Ms (Mishima Mus musculus molossinus) strain. (J:323200)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pak1 Mutation:  37 strains or lines available
References
Original:  J:323200 Okumura K, et al., Functional Polymorphism in Pak1-3' Untranslated Region Alters Skin Tumor Susceptibility by Alternative Polyadenylation. J Invest Dermatol. 2022 Mar 1;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory