Itgb2tm1.1(ITGB2)Kley
Targeted Allele Detail
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Symbol: |
Itgb2tm1.1(ITGB2)Kley |
Name: |
integrin beta 2; targeted mutation 1.1, Klaus Ley |
MGI ID: |
MGI:7284875 |
Synonyms: |
hITGB2 KI |
Gene: |
Itgb2 Location: Chr10:77366164-77401542 bp, + strand Genetic Position: Chr10, 39.72 cM
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Alliance: |
Itgb2tm1.1(ITGB2)Kley page
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Germline Transmission: |
Earliest citation of germline transmission:
J:325332
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6N
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Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout) |
Mutation: |
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Insertion
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Itgb2tm1.1(ITGB2)Kley expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
ITGB2 (3689) |
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Mutation details: The targeting cassette contains a loxP site, followed by an FRT-flanked neomycin selection cassette, the human ITGB2 isoform 1 cDNA, polyA sequence and a second loxP site inserted into exon 2 of the gene. The insertion of this cassette results in disruption of the endogenous gene and no mouse Itgb2 is expressed. Flp-mediated recombination removed the neo cassette.
(J:325332)
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Original: |
J:325332 Wen L, et al., A humanized beta2 integrin knockin mouse reveals localized intra- and extravascular neutrophil integrin activation in vivo. Cell Rep. 2022 May 31;39(9):110876 |
All: |
1 reference(s) |
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