Tbc1d7^em1Hms
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tbc1d7^em1Hms
• Name: TBC1 domain family, member 7; endonuclease-mediated mutation 1, Harvard Medical School
• MGI ID: MGI:7286317
• Gene: Tbc1d7 Location: Chr13:43305216-43324977 bp, - strand Genetic Position: Chr13, 21.31 cM, cytoband A5
• Alliance: Tbc1d7^em1Hms page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting produced a 35 bp out-of-frame deletion in exon 3. (J:325096)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbc1d7 Mutation: 22 strains or lines available

References

• Original: J:325096 Schrotter S, et al., The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth. Cell Rep. 2022 May 17;39(7):110824
• All: 1 reference(s)