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Specc1lem2Kumc
Endonuclease-mediated Allele Detail
Summary
Symbol: Specc1lem2Kumc
Name: sperm antigen with calponin homology and coiled-coil domains 1-like; endonuclease-mediated mutation 2, University of Kansas Medical Center
MGI ID: MGI:7286333
Synonyms: Specc1ldeltaEx4
Gene: Specc1l  Location: Chr10:75047872-75148234 bp, + strand  Genetic Position: Chr10, 38.51 cM
Alliance: Specc1lem2Kumc page
Mutation
origin
Strain of Origin:  (C57BL/6J x FVB/NJ)F1
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCRISPR/cas9 mediated recombination using 2 guide RNAs targeting exon 4 created a deletion mutation. Western blot analysis confirmed the absence of protein expression. (J:324294)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Specc1l Mutation:  51 strains or lines available
References
Original:  J:324294 Goering JP, et al., In-frame deletion of SPECC1L microtubule association domain results in gain-of-function phenotypes affecting embryonic tissue movement and fusion events. Hum Mol Genet. 2021 Dec 17;31(1):18-31
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory