Ccdc38^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ccdc38^em1Cya
• Name: coiled-coil domain containing 38; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:7287391
• Synonyms: Ccdc38^-, Ccdc38^em1cyagen
• Gene: Ccdc38 Location: Chr10:93376494-93420189 bp, + strand Genetic Position: Chr10, 48.55 cM
• Alliance: Ccdc38^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology deleted exons 5-11. Western blot analysis confirmed the complete absence of encoded protein in total protein extracts from homozygous mutant testes. (J:325559)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ccdc38 Mutation: 37 strains or lines available

References

• Original: J:325559 Zhang R, et al., CCDC38 is required for sperm flagellum biogenesis and male fertility in mice. Development. 2022 Jun 1;149(11):dev200516
• All: 1 reference(s)