Pvrig^tm1.1Sgng
Targeted Allele Detail

Summary

• Symbol: Pvrig^tm1.1Sgng
• Name: poliovirus receptor related immunoglobulin domain containing; targeted mutation 1, Sudipto Ganguly
• MGI ID: MGI:7287533
• Gene: Pvrig Location: Chr5:138340223-138341819 bp, + strand Genetic Position: Chr5, Syntenic
• Alliance: Pvrig^tm1.1Sgng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:324171
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct floxed exon 1 through 4. Flp-mediated recombination removed the selection cassette. (J:324171)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pvrig Mutation: 10 strains or lines available

References

• Original: J:324171 Murter B, et al., Mouse PVRIG Has CD8(+) T Cell-Specific Coinhibitory Functions and Dampens Antitumor Immunity. Cancer Immunol Res. 2019 Feb;7(2):244-256
• All: 1 reference(s)