Igs2em5(CAG-Myc)Smoc
Endonuclease-mediated Allele Detail
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Symbol: |
Igs2em5(CAG-Myc)Smoc |
Name: |
intergenic site 2; endonuclease-mediated mutation 5, Shanghai Model Organisms Center |
MGI ID: |
MGI:7290389 |
Synonyms: |
Igs2em1(CAG-LSL-Myc)Smoc, MycTg |
Gene: |
Igs2 Location: unknown Genetic Position: Chr11, Syntenic
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Alliance: |
Igs2em5(CAG-Myc)Smoc page
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Allele Type: |
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Endonuclease-mediated (Conditional ready, Inserted expressed sequence) |
Mutation: |
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Insertion
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Igs2em5(CAG-Myc)Smoc expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
MYC (4609) |
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Mutation details: The c-Myc gene (also known as Myc) is abnormally expressed in many tumors and plays a critical role in the regulation of cell proliferation, growth and metabolism, gene instability, stimulation of angiogenesis, malignant transformation, cell differentiation and apoptosis. These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Myc oncogene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination. Myc is expressed when bred to mice that express Cre recombinase.
(J:338536)
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Inheritance: |
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Not Specified |
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Igs2 Mutation: |
71 strains or lines available
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Original: |
J:338536 Wei T, et al., Loss of Mettl3 enhances liver tumorigenesis by inducing hepatocyte dedifferentiation and hyperproliferation. Cell Rep. 2023 Jul 25;42(7):112704 |
All: |
1 reference(s) |
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