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Tnfrsf1aem2Smoc
Endonuclease-mediated Allele Detail
Summary
Symbol: Tnfrsf1aem2Smoc
Name: tumor necrosis factor receptor superfamily, member 1a; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
MGI ID: MGI:7292882
Gene: Tnfrsf1a  Location: Chr6:125326686-125339446 bp, + strand  Genetic Position: Chr6, 59.32 cM
Alliance: Tnfrsf1aem2Smoc page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis strain is also called p55/p75-KO. The Tnfrsf1a and Tnfrsf1b double knockout mouse models were obtained by knocking out both exon 2-5 region of mouse Tnfrsf1a gene and exon2 of mouse Tnfrsf1b gene. Tnfrsf1a and Tnfrsf1b deletion (p55 and p75 deficiency) homozygous mice are viable and fertile, and these homozygous mice fail to bind TNF (tumor necrosis factor). (J:238766)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfrsf1a Mutation:  52 strains or lines available
References
Original:  J:238766 Shanghai Model Organisms Center, Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China. MGI Direct Data Submission. 2017;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory