Tnfrsf1b^em1Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tnfrsf1b^em1Smoc
• Name: tumor necrosis factor receptor superfamily, member 1b; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:7292884
• Gene: Tnfrsf1b Location: Chr4:144940033-144973440 bp, - strand Genetic Position: Chr4, 78.17 cM
• Alliance: Tnfrsf1b^em1Smoc page

Mutation origin

• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This strain is also called p55/p75-KO. The Tnfrsf1a and Tnfrsf1b double knockout mouse models were obtained by knocking out both exon 2-5 region of mouse Tnfrsf1a gene and exon2 of mouse Tnfrsf1b gene. Tnfrsf1a and Tnfrsf1b deletion (p55 and p75 deficiency) homozygous mice are viable and fertile, and these homozygous mice fail to bind TNF (tumor necrosis factor). (J:238766)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf1b Mutation: 41 strains or lines available

References

• Original: J:238766 Shanghai Model Organisms Center, Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China. MGI Direct Data Submission. 2017
• All: 2 reference(s)