Dgkh^tm1Skne
Targeted Allele Detail

Summary

• Symbol: Dgkh^tm1Skne
• Name: diacylglycerol kinase, eta; targeted mutation 1, Fumio Sakane
• MGI ID: MGI:7294346
• Gene: Dgkh Location: Chr14:78796789-78970169 bp, - strand Genetic Position: Chr14, 41.56 cM
• Alliance: Dgkh^tm1Skne page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234190
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct part of the catalytic domain encoded by exons 5 and 6 with a neomycin resistance cassette flanked by recombinase sites. (J:234190)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dgkh Mutation: 57 strains or lines available

References

• Original: J:234190 Isozaki T, et al., Deficiency of diacylglycerol kinase eta induces lithium-sensitive mania-like behavior. J Neurochem. 2016 Aug;138(3):448-56
• All: 3 reference(s)