Adam21^em1Liwe
Endonuclease-mediated Allele Detail

Summary

• Symbol: Adam21^em1Liwe
• Name: a disintegrin and metallopeptidase domain 21; endonuclease-mediated mutation 1, Wei Li
• MGI ID: MGI:7294347
• Synonyms: Adam21^-
• Gene: Adam21 Location: Chr12:81605358-81615248 bp, - strand Genetic Position: Chr12, 37.79 cM
• Alliance: Adam21^em1Liwe page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology was used to target the entire open reading frame and create a deletion of 2,324 bp in exon 2. Quantitative RT-PCR analysis confirmed the complete absence of mRNA expression in the testes of homozygous mutant mice. (J:324150)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adam21 Mutation: 37 strains or lines available

References

• Original: J:324150 Chen Y, et al., Adam21 is dispensable for reproductive processes in mice. PeerJ. 2021;9:e12210
• All: 1 reference(s)