Drc1^em3Mngx
Endonuclease-mediated Allele Detail

Summary

• Symbol: Drc1^em3Mngx
• Name: dynein regulatory complex subunit 1; endonuclease-mediated mutation 2, Mingxi Liu
• MGI ID: MGI:7294420
• Synonyms: Drc1^W244X
• Gene: Drc1 Location: Chr5:30486386-30524039 bp, + strand Genetic Position: Chr5, 16.42 cM
• Alliance: Drc1^em3Mngx page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: This gene was targeted for single base substitution using a third generation base editor (BE3). This allele has a mutation of TGGG sequence to TAAA, resulting in a stop-gain at tryptophan 244 (p.W244*). Western blot analysis confirmed the absence of protein expression in testis samples from homozygous mutant males. (J:322334)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Drc1 Mutation: 36 strains or lines available

References

• Original: J:322334 Zhang J, et al., Loss of DRC1 function leads to multiple morphological abnormalities of the sperm flagella and male infertility in human and mouse. Hum Mol Genet. 2021 Oct 13;30(21):1996-2011
• All: 1 reference(s)