Tm9sf5^em1Dzha
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tm9sf5^em1Dzha
• Name: transmembrane 9 superfamily member 5; endonuclease-mediated mutation 1, Dong Zhang
• MGI ID: MGI:7294424
• Synonyms: Gm364^-
• Gene: Tm9sf5 Location: ChrX:56454514-56534127 bp, + strand Genetic Position: ChrX, 31.71 cM
• Alliance: Tm9sf5^em1Dzha page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 55 bp deletion in exon 1 resulting in a frameshift. Western blot and immunofluorescence analyses confirmed the absence of protein in oocytes from homozygous mutant mice. (J:320690)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tm9sf5 Mutation: 0 strains or lines available

References

• Original: J:320690 Chen LJ, et al., Gm364 coordinates MIB2/DLL3/Notch2 to regulate female fertility through AKT activation. Cell Death Differ. 2022 Feb;29(2):366-380
• All: 1 reference(s)