Rnf216^em1Lijd
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rnf216^em1Lijd
• Name: ring finger protein 216; endonuclease-mediated mutation 1, Jia-Da Li
• MGI ID: MGI:7294478
• Synonyms: Rnf216^-
• Gene: Rnf216 Location: Chr5:142976648-143098749 bp, - strand Genetic Position: Chr5, 81.86 cM, cytoband G2
• Alliance: Rnf216^em1Lijd page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 311 bp deletion within exons 4 and 5. Western blot analysis confirmed absence of protein in testes. (J:307636)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnf216 Mutation: 53 strains or lines available

References

• Original: J:307636 Li D, et al., RNF216 regulates meiosis and PKA stability in the testes. FASEB J. 2021 Apr;35(4):e21460
• All: 1 reference(s)