Tmcc2^em1Tar
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tmcc2^em1Tar
• Name: transmembrane and coiled-coil domains 2; endonuclease-mediated mutation 1, University of Warsaw
• MGI ID: MGI:7294527
• Gene: Tmcc2 Location: Chr1:132284053-132319019 bp, - strand Genetic Position: Chr1, 57.24 cM
• Alliance: Tmcc2^em1Tar page

Mutation origin

• Strain of Origin: (C57BL/6JTar x CBA/WTar)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting deleted 11 bp (c.835_845del11b; ENSMUST00000045473.15 p.279X) and introduced a stop codon into all isoforms. (J:325992)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmcc2 Mutation: 30 strains or lines available

References

• Original: J:325992 Kumari R, et al., Ablation of Tmcc2 Gene Impairs Erythropoiesis in Mice. Int J Mol Sci. 2022 May 9;23(9)
• All: 1 reference(s)