Tmco1^tm1Tsta
Targeted Allele Detail

Summary

• Symbol: Tmco1^tm1Tsta
• Name: transmembrane and coiled-coil domains 1; targeted mutation 1, Tie-Shan Tang
• MGI ID: MGI:7294562
• Synonyms: Tmco1^-
• Gene: Tmco1 Location: Chr1:167136239-167161547 bp, + strand Genetic Position: Chr1, 74.69 cM
• Alliance: Tmco1^tm1Tsta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:268917
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S3/SvImJ and C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked PGK-neomycin selection cassette replaced a 1.01-kb fragment containing the coding region of exons 1 and 2. Western blot analysis confirmed the absence of protein expression in ovary samples and granulosa cells and germinal vesicle (GV)-stage oocytes isolated from homozygous mutant females. (J:268917)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmco1 Mutation: 43 strains or lines available

References

• Original: J:268917 Sun Z, et al., TMCO1 is essential for ovarian follicle development by regulating ER Ca(2+) store of granulosa cells. Cell Death Differ. 2018 Sep;25(9):1686-1701
• All: 1 reference(s)