Dmc1^em1Jcs
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dmc1^em1Jcs
• Name: DNA meiotic recombinase 1; endonuclease-mediated mutation 1, John C Schimenti
• MGI ID: MGI:7294565
• Synonyms: DMC1^M200V
• Gene: Dmc1 Location: Chr15:79445698-79489310 bp, - strand Genetic Position: Chr15, 37.79 cM, cytoband E
• Alliance: Dmc1^em1Jcs page

Mutation origin

• Strain of Origin: (FVB/NJ x B6(Cg)-Tyr^c-2J/J)F1

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology generated a two nucleotide change, ATG to GTA, in codon 200 resulting in a methionine to valine substitution at amino acid 200. (J:267449)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dmc1 Mutation: 17 strains or lines available

References

• Original: J:267449 Tran TN, et al., A putative human infertility allele of the meiotic recombinase DMC1 does not affect fertility in mice. Hum Mol Genet. 2018 Nov 15;27(22):3911-3918
• All: 1 reference(s)