Ccdc65^em11Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ccdc65^em11Gpt
• Name: coiled-coil domain containing 65; endonuclease-mediated mutation 11, GemPharmatech Co., Ltd
• MGI ID: MGI:7296395
• Synonyms: CCDC65^-, Ccdc65^em11Cd9080
• Gene: Ccdc65 Location: Chr15:98606088-98621217 bp, + strand Genetic Position: Chr15, 54.65 cM
• Alliance: Ccdc65^em11Gpt page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting introduced a coding region modification (del9080). Exons 2-3 were targeted for deletion. mRNA and protein levels were reduced by half in lung tissues from heterozygous mutant mice. Western blot analysis confirmed the absence of protein expression in lung tissues from homozygous mutant mice. (J:293217)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccdc65 Mutation: 16 strains or lines available

References

• Original: J:293217 GemPharmatech, GemPharmatech Website. 2020
• All: 2 reference(s)