Csta1^em1Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Csta1^em1Gpt
• Name: cystatin A1; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
• MGI ID: MGI:7297511
• Synonyms: Csta1^em1Cflox
• Gene: Csta1 Location: Chr16:35940316-35951559 bp, - strand Genetic Position: Chr16, 25.43 cM
• Alliance: Csta1^em1Gpt page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR-targeting floxed exons 2 and 3. (J:340112)
• Inheritance: Not Specified

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Csta1^em1Gpt/Csta1^em1Gpt	C57BL/6JGpt-Csta1^em1Gpt

Phenotypes:

Affected Systems	cn1
show or hide all annotated terms
cellular	√
decreased keratinocyte proliferation	√
integument	√
decreased keratinocyte proliferation	√
abnormal keratinocyte morphology	√
thin epidermis	√
skeleton	√
decreased bone mineral density	√
decreased compact bone mass	√
decreased osteoblast cell number	√
decreased trabecular bone mass	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Csta1 Mutation: 9 strains or lines available

References

• Original: J:340112 Liang W, et al., Skin chronological aging drives age-related bone loss via secretion of cystatin-A. Nat Aging. 2022 Oct;2(10):906-922
• All: 1 reference(s)