Acss2^em22Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Acss2^em22Gpt
• Name: acyl-CoA synthetase short-chain family member 2; endonuclease-mediated mutation 22, GemPharmatech Co., Ltd
• MGI ID: MGI:7309378
• Synonyms: ACSS2^-, Acss2^em22Cd4454, ACSS2 KO
• Gene: Acss2 Location: Chr2:155359963-155404663 bp, + strand Genetic Position: Chr2, 77.26 cM, cytoband H2
• Alliance: Acss2^em22Gpt page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting introduced a coding region modification (del4454). Western blotting and immunofluorescence analyses of kidney tissues confirmed the absence of protein expression in homozygous mutant mice. LPS treatment failed to increase the protein levels of ACSS2 in mutant kidneys, unlike in wild-type controls. (J:293217)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acss2 Mutation: 53 strains or lines available

References

• Original: J:293217 GemPharmatech, GemPharmatech Website. 2020
• All: 2 reference(s)