Xrcc3^em2Mjn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Xrcc3^em2Mjn
• Name: X-ray repair complementing defective repair in Chinese hamster cells 3; endonuclease-mediated mutation 2, Maria Jasin
• MGI ID: MGI:7310058
• Synonyms: Xrcc3 KA
• Gene: Xrcc3 Location: Chr12:111769626-111780307 bp, - strand Genetic Position: Chr12, 61.14 cM
• Alliance: Xrcc3^em2Mjn page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: TALEN-targeting of exon 4 inserted the modification that results in the amino acid substitution of lysine with alanine at position 113 (K113A). (J:320381)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Xrcc3 Mutation: 16 strains or lines available

References

• Original: J:320381 Prakash R, et al., XRCC3 loss leads to midgestational embryonic lethality in mice. DNA Repair (Amst). 2021 Dec;108:103227
• All: 1 reference(s)