Emc10^tm1.2Smoc
Targeted Allele Detail

Summary

• Symbol: Emc10^tm1.2Smoc
• Name: ER membrane protein complex subunit 10; targeted mutation 1.2, Shanghai Model Organisms Center
• MGI ID: MGI:7310069
• Synonyms: Emc10^-
• Gene: Emc10 Location: Chr7:44139361-44145953 bp, - strand Genetic Position: Chr7, 28.83 cM
• Alliance: Emc10^tm1.2Smoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:307574
• Parent Cell Line: PRX-129S6 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was flanked by loxP sites and an FRT-flanked neomycin resistance gene was inserted downstream of the floxed exon 2. The selection cassette was removed via flp-mediated recombination and exon 2 was deleted via cre-mediated recombination. (J:307574)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Emc10 Mutation: 19 strains or lines available

References

• Original: J:307574 Zhou Y, et al., EMC10 governs male fertility via maintaining sperm ion balance. J Mol Cell Biol. 2018 Dec 1;10(6):503-514
• All: 2 reference(s)