Aqp5^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Aqp5^em1Cya
• Name: aquaporin 5; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:7310129
• Synonyms: Aqp5^em1Cd
• Gene: Aqp5 Location: Chr15:99488909-99492710 bp, + strand Genetic Position: Chr15, 56.13 cM
• Alliance: Aqp5^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology targeted exons 1 to 4 for deletion created a 4569 bp deletion. (J:326269, J:324867)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aqp5 Mutation: 19 strains or lines available

References

• Original: J:326269 Liu Y, et al., Expression Profiles of CircRNA and mRNA in Lacrimal Glands of AQP5(-/-) Mice With Primary Dry Eye. Front Physiol. 2020;11:1010
• All: 7 reference(s)