Axdnd1^em1Ktmr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Axdnd1^em1Ktmr
• Name: axonemal dynein light chain domain containing 1; endonuclease-mediated mutation 1, Kentaro Tanemura
• MGI ID: MGI:7310205
• Gene: Axdnd1 Location: Chr1:156157985-156248743 bp, - strand Genetic Position: Chr1, 67.71 cM
• Alliance: Axdnd1^em1Ktmr page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of the exon encoding the axonemal dynein light chain domain deleted 10 bp (CGTTGCTCAA) resulting in premature termination. (J:324162)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Axdnd1 Mutation: 46 strains or lines available

References

• Original: J:324162 Hiradate Y, et al., Loss of Axdnd1 causes sterility due to impaired spermatid differentiation in mice. Reprod Med Biol. 2022 Jan-Dec;21(1):e12452
• All: 1 reference(s)