Akr1c14^tm1.1Penn
Targeted Allele Detail

Summary

• Symbol: Akr1c14^tm1.1Penn
• Name: aldo-keto reductase family 1, member C14; targeted mutation 1.1, Anna Penn
• MGI ID: MGI:7310293
• Synonyms: akr1c14^fl, Akr1c14^tm1Itl
• Gene: Akr1c14 Location: Chr13:4099015-4140569 bp, + strand Genetic Position: Chr13, 2.26 cM
• Alliance: Akr1c14^tm1.1Penn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:323376
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a loxP-FRT-flanked neo selection cassette upstream of exon 7. A second single loxP site was inserted just 5' of exon 10. FLP-mediated recombination removed the neo cassette. (J:323376)

Expression

In Mice Carrying this Mutation:

48 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Akr1c14 Mutation: 25 strains or lines available

Notes

ES cell = BA1

References

• Original: J:323376 Vacher CM, et al., Placental endocrine function shapes cerebellar development and social behavior. Nat Neurosci. 2021 Oct;24(10):1392-1401
• All: 2 reference(s)