Mir592^em1Jzhan
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mir592^em1Jzhan
• Name: microRNA 592; endonuclease-mediated mutation 1, Jing Zhang
• MGI ID: MGI:7310355
• Synonyms: miR-592^-
• Gene: Mir592 Location: Chr6:27936654-27936749 bp, - strand Genetic Position: Chr6, 11.99 cM
• Alliance: Mir592^em1Jzhan page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 157 bp deletion in the untranslated exon region of Grm8. Mir592 is in this untranslated exon region and RT-PCR confirmed knock-out of Mir592. Isoform-sequencing indicates that Grm8 is not affected by knocking out Mir592. (J:323615)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir592 Mutation: 1 strain or line available

References

• Original: J:323615 Fu Y, et al., Loss of neurodevelopmental-associated miR-592 impairs neurogenesis and causes social interaction deficits. Cell Death Dis. 2022 Apr 1;13(4):292
• All: 1 reference(s)