Nucb2^tm1.2Vdix
Targeted Allele Detail

Summary

• Symbol: Nucb2^tm1.2Vdix
• Name: nucleobindin 2; targeted mutation 1.2, Vishwa Deep Dixit
• MGI ID: MGI:7310447
• Gene: Nucb2 Location: Chr7:116103604-116139819 bp, + strand Genetic Position: Chr7, 61.79 cM
• Alliance: Nucb2^tm1.2Vdix page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:270674
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct inserted a loxP site upstream of exon 3 and an FRT-flanked neomycin resistance cassette with a 3' loxP site downstream of exon 3. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 3. (J:270674)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nucb2 Mutation: 30 strains or lines available

References

• Original: J:270674 Ravussin A, et al., Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity. Cell Rep. 2018 Jul 31;24(5):1085-1092.e6
• All: 1 reference(s)