Tardbp^tm1.1Sobue
Targeted Allele Detail

Summary

• Symbol: Tardbp^tm1.1Sobue
• Name: TAR DNA binding protein; targeted mutation 1.1, Gen Sobue
• MGI ID: MGI:7311560
• Synonyms: TDP-43^flox
• Gene: Tardbp Location: Chr4:148696839-148711476 bp, - strand Genetic Position: Chr4, 78.77 cM
• Alliance: Tardbp^tm1.1Sobue page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:324570
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin cassette and loxP site were inserted upstream of exon 2 and a second loxP site was inserted downstream of exon 2. The neomycin cassette was removed via flp-mediated recombination leaving exon 2 floxed. (J:324570)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tardbp Mutation: 68 strains or lines available

References

• Original: J:324570 Iguchi Y, et al., Loss of TDP-43 causes age-dependent progressive motor neuron degeneration. Brain. 2013 May;136(Pt 5):1371-82
• All: 2 reference(s)