Rarres1^{tm1d(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Rarres1^{tm1d(KOMP)Wtsi}
• Name: retinoic acid receptor responder (tazarotene induced) 1; targeted mutation 1d, Wellcome Trust Sanger Institute
• MGI ID: MGI:7311664
• Gene: Rarres1 Location: Chr3:67386305-67422856 bp, - strand Genetic Position: Chr3, 30.99 cM
• Alliance: Rarres1^{tm1d(KOMP)Wtsi} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:324270
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 67398012 of Chromosome 3 upstream of the critical exon 3 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 3 at position 67398906. The critical exon is thus flanked by loxP sites. Flp-mediated recombination removed the lacZ and neomycin resistance gene and cre-mediated recombination deleted exon 3. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:324270)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rarres1 Mutation: 14 strains or lines available

References

• Original: J:324270 Patel J, et al., Loss of RARRES1 function Promotes Follicular Lymphomagenesis and Inhibits B cell Differentiation in Mice. Int J Biol Sci. 2022;18(7):2670-2682
• All: 1 reference(s)