Sh3rf1^em1Bcgen
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sh3rf1^em1Bcgen
• Name: SH3 domain containing ring finger 1; endonuclease-mediated mutation 1, Biocytogen LLC
• MGI ID: MGI:7312050
• Synonyms: POSH flox
• Gene: Sh3rf1 Location: Chr8:61676906-61849105 bp, + strand Genetic Position: Chr8, 30.94 cM
• Alliance: Sh3rf1^em1Bcgen page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: CRISPR-targeting inserted a loxP site, open reading frame with UTR, polyadenylation sequence, loxP site, and a triple stop sequence in exon 3. (J:326378)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sh3rf1 Mutation: 54 strains or lines available

References

• Original: J:326378 Yao M, et al., POSH regulates assembly of the NMDAR/PSD-95/Shank complex and synaptic function. Cell Rep. 2022 Apr 5;39(1):110642
• All: 1 reference(s)