Gsdma^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gsdma^em1Cya
• Name: gasdermin A; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:7312160
• Gene: Gsdma Location: Chr11:98555177-98568534 bp, + strand Genetic Position: Chr11, 62.34 cM
• Alliance: Gsdma^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Not Specified
• CRISPR-targeting of exons 2 through 12 generated a null allele. (J:326434)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gsdma Mutation: 24 strains or lines available

References

• Original: J:326434 Deng W, et al., Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis. Nature. 2022 Feb;602(7897):496-502
• All: 1 reference(s)