Cyp26b1^em1Oncl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cyp26b1^em1Oncl
• Name: cytochrome P450, family 26, subfamily b, polypeptide 1; endonuclease-mediated mutation 1, Ondine Cleaver
• MGI ID: MGI:7314519
• Synonyms: Cyp26b1^-
• Gene: Cyp26b1 Location: Chr6:84548396-84570890 bp, - strand Genetic Position: Chr6, 36.45 cM
• Alliance: Cyp26b1^em1Oncl page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination created an in-frame 2.6 kb deletion spanning from exon 3 to exon 6. (J:291486)

Expression

In Mice Carrying this Mutation:	132 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp26b1 Mutation: 35 strains or lines available

References

• Original: J:291486 Daniel E, et al., Cyp26b1 is an essential regulator of distal airway epithelial differentiation during lung development. Development. 2020 Feb 20;147(4):dev181560
• All: 2 reference(s)