Igs2^{tm1(CAG-Ptgs2os)Scrp}
Targeted Allele Detail

Summary

• Symbol: Igs2^{tm1(CAG-Ptgs2os)Scrp}
• Name: intergenic site 2; targeted mutation 1, Susan Carpenter
• MGI ID: MGI:7314909
• Synonyms: lincRNA-Cox2 (Tg)
• Gene: Igs2 Location: Chr11:3195460-3195497 bp Genetic Position: Chr11, Syntenic
• Alliance: Igs2^{tm1(CAG-Ptgs2os)Scrp} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:325487
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Igs2^{tm1(CAG-Ptgs2os)Scrp} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ptgs2os (MGI:2443180)

• Mutation details: Site-specific integrase-mediated recombination inserted a CAG promoter driving ubiquitous expression of Ptgs2os. (J:325487)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Igs2 Mutation: 72 strains or lines available

References

• Original: J:325487 Robinson EK, et al., lincRNA-Cox2 Functions to Regulate Inflammation in Alveolar Macrophages during Acute Lung Injury. J Immunol. 2022 Apr 15;208(8):1886-1900
• All: 1 reference(s)