Tg(NKX2-5*-cre)#Kyuhl
Transgene Detail

Summary

• Symbol: Tg(NKX2-5*-cre)#Kyuhl
• Name: transgene insertion, Kyu-Ho Lee
• MGI ID: MGI:7314947
• Synonyms: CNkx2.5-SHFnm-cre
• Transgene: Tg(NKX2-5*-cre)#Kyuhl Location: unknown Genetic Position: ChrUN, Syntenic
• Alliance: Tg(NKX2-5*-cre)#Kyuhl page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(NKX2-5*-cre)#Kyuhl expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  chicken	NKX2-5 (396073)

• Mutation details: A mutated version of the chicken second heart field (SHF) NK2 homeobox 5 enhancer (cardiac activating region 3 (CAR3); nucleotides 976-3047 after transcriptional start site), where the Nkx2-5-binding consensus sequence in the BMP response element (BMPRE) was mutated from TCTGAGTG to TCTGCGAG, was used to drive the expression of the cre recombinase gene. Founder information and line numbers were not available. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:192448)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	NKX2-5 (chicken) Summary of all recombinase alleles driven by NKX2-5. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:192448 Clark CD, et al., Evolutionary conservation of Nkx2.5 autoregulation in the second heart field. Dev Biol. 2013 Feb 1;374(1):198-209
• All: 1 reference(s)